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Cyclodextrin | 环状糊精

产品编号:C1750

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Cyclodextrin (CD)

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环状糊精
 
                                                      
                                                          Extended Reference;Chemical and Physical Properties of Cyclodextrins   
                                                                                        
Cat No CAS No. NAME/ Chinese Name Storage Molecular Formular Glucose Unites MW Cavity diameter Purity/Grade Package/Your Price
C1750A 10016-20-3 α-cyclodextrin | α-环状糊精 RT C36H60O30 6 972.84 About 0.6 nm ≥98% BioReagent 1G 135 5G 324 25G 1289
C1750B 7585-39-9 β-cyclodextrin |  β-环状糊精 RT C42H70O35 7 1134.98 0.7 to 0.8 nm ≥98% BioReagent 5G 327 25G 756 100G 2349
C1750G 17465-86-0 γ-cyclodextrin | γ-环状糊精 RT C48H80O40 8 1297.12 0.9 to 1.0 nm ≥98% BioReagent 0.5G 856 1G 1576 5G 3247








Cyclodextrins (sometimes called cycloamyloses) are a family of compounds made up of sugar molecules bound together in a ring (cyclicoligosaccharides).
Cyclodextrins are produced from starch by means of enzymatic conversion. They are used in food, pharmaceutical, drug delivery and chemical industries, as well as agriculture and environmental engineering.
Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). The 5-membered macrocycle is not natural. Recently, the largest well-characterized cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, at least 150-membered cyclic oligosaccharides are also known. Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape:
        α (alpha)-cyclodextrin: 6-membered sugar ring molecule
        β (beta)-cyclodextrin: 7-membered sugar ring molecule
        γ (gamma)-cyclodextrin: 8-membered sugar ring molecule
α- and γ-cyclodextrin are being used in the food industry. As α-cyclodextrin is a soluble dietary fiber, it can be found as Alpha Cyclodextrin (soluble fiber) on the list of ingredients of commercial products.
α-cyclodextrin β-cyclodextrin γ-cyclodextrin
Fig. Chemical structure of the three main types of cyclodextrins.

TABLE Types and features of cyclodextrin  
Name Glucose Unite MW Cavitydiameter CAS No.  Solubility
α-cyclodextrin 6 972 About 0.6 nm 10016-20-3  
β-cyclodextrin 7 1,135 0.7 to 0.8 nm 7585-39-9  
γ-cyclodextrin 8 1,297 0.9 to 1.0 nm 17465-86-0 23.2 g/100ml @25C


Application in Biology and BioIndustry
1. Use in  biological research
Cyclodextrins are molecules used to solublize non-polar molecules such a cholesterol for use in cell culture.
2. Increasing bioavailability
Because cyclodextrins are hydrophobic inside and hydrophilic outside, they can form complexes with hydrophobic compounds. Thus they can enhance the solubility and bioavailability of such compounds. This is of high interest for pharmaceutical as well as dietary supplement applications in which hydrophobic compounds shall be delivered. Alpha-, beta-, and gamma-cyclodextrin are all generally recognized as safe by the FDA.
3. Cholesterol free products
In the food industry, cyclodextrins are employed for the preparation of cholesterol free products: the bulky and hydrophobic cholesterol molecule is easily lodged inside cyclodextrin rings that are then removed.
4. Multifunctional dietary fiber
α-Cyclodextrin has been authorized for use as a dietary fiber in the European Union since 2008. In 2013 the EU commission has verified a health claim for alpha-cyclodextrin. The EU assessment report confirms that consumption of alpha-cyclodextrin can reduce blood sugar peaks following a high-starch meal. Weight loss supplements are marketed from alpha-cyclodextrin which claim to bind to fat and be an alternative to other anti-obesity medications.
Due to its surface-active properties, α-cyclodextrin can also be used as emulsifying fiber, for example in mayonnaise as well as a whipping aid, for example in desserts and confectionary applications.
4. Other food applications
Applications further include the ability to stabilize volatile or unstable compounds and the reduction of unwanted tastes and odour. Beta-cyclodextrin complexes with certain carotenoid food colorants have been shown to intensify color, increase water solubility and improve light stability.
The strong ability of complexing fragrances can also be used for another purpose: first dry, solid cyclodextrin microparticles are exposed to a controlled contact with fumes of active compounds, then they are added to fabric or paper products. Such devices are capable of releasing fragrances during ironing or when heated by human body. Such a device commonly used is a typical 'dryer sheet'. The heat from a clothes dryer releases the fragrance into the clothing.
Cyclodextrins are also used to produce alcohol powder by encapsulating ethanol. The powder produces an alcoholic beverage when mixed with water.
5. Aerosols
Aqueous cyclodextrin solutions can generate aerosols in particle size ranges suitable for pulmonary deposition. Large quantities of aerosol can be nebulized in acceptable nebulization times. The cyclodextrin concentration does not modify nebulization efficiency in the range tested.
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